Autophagy in ageing and ageing-associated diseases
نویسندگان
چکیده
منابع مشابه
Autophagy and ageing: implications for age-related neurodegenerative diseases.
Autophagy is a process of lysosome-dependent intracellular degradation that participates in the liberation of resources including amino acids and energy to maintain homoeostasis. Autophagy is particularly important in stress conditions such as nutrient starvation and any perturbation in the ability of the cell to activate or regulate autophagy can lead to cellular dysfunction and disease. An ar...
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Macroautophagy is a degradation/recycling system ubiquitous in eukariotic cells, which generates nutrients during fasting under the control of amino acids and hormones, and contributes to the turnover and rejuvenation of cellular components (long-lived proteins, cytomembranes and organelles). Tight coupling between these two functions may be the weak point in cell housekeeping. Ageing denotes a...
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Increases in human lifespan worldwide have revealed that advancing age is the predominant risk factor for major life-threatening diseases. Recent work has shown that ageing in diverse animals, including humans, is malleable to specific types of genetic mutation, diet, and drugs that can extend lifespan and improve health during ageing. These findings point to the prospect of broad-spectrum prev...
متن کاملDiseases of ageing in Ghana.
OBJECTIVE The objective of the paper was to outline the chronic non-communicable disease burden of older adults and predict the odds of living with a chronic non-communicable disease in Ghana. DESIGN The paper utilized descriptive and analytical statistical methods to assess the level of chronic noncommunicable diseases among older adults. SETTING Data from the Study on Global Ageing and Ad...
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With more and more treatments becoming available for people with rare diseases, we encounter the issue of ageing more often. A number of patients with rare, chronic diseases have experienced a number of remarkable transitions in their lives. The most important transition is the one from no treatment at all to treatment becoming available, like in haemophilia about 45 years ago. Another transiti...
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ژورنال
عنوان ژورنال: Acta Pharmacologica Sinica
سال: 2013
ISSN: 1671-4083,1745-7254
DOI: 10.1038/aps.2012.188